APIK Journal of Internal Medicine

: 2020  |  Volume : 8  |  Issue : 3  |  Page : 149-

Scientist Review

Swetha Amaresh 
 Consultant Physician, Highborn Polyclinic, Kalaburagi, Gulbarga, Karnataka, India

Correspondence Address:
Dr. Swetha Amaresh
Highborn Polyclinic, Veerashaiva Complex, Sedam Road, Kalaburagi, Gulbarga, Karnataka

How to cite this article:
Amaresh S. Scientist Review.APIK J Int Med 2020;8:149-149

How to cite this URL:
Amaresh S. Scientist Review. APIK J Int Med [serial online] 2020 [cited 2020 Sep 30 ];8:149-149
Available from: http://www.ajim.in/text.asp?2020/8/3/149/289790

Full Text



Japanese researcher Dr. Akira Endo who was born on November 14, 1933, in Higashiyuri is an alma mater of Tohoku University. He obtained his BA at Tohoku University in Sendal in 1957 and a PhD in biochemistry in the same university in 1966. He worked as research associate at Albert Einstein College of Medicine between 1966 and 1968, working on cholesterol.

He hypothesized that fungi used chemicals to ward off parasitic organisms by inhibiting cholesterol synthesis. The fungi contain ergosterol in place of cholesterol, allowing them to produce chemicals that inhibit cholesterol.

Among many compounds studied by Dr. Endo three from Penicillium citrinum mold showed an effect. Mevastatin was the first member of the statin class of drugs, HMG Co A reductase inhibitor class. Although mevastatin never became an approved drug, statins are the cornerstone of cholesterol management. For decades, now, statins have stood the test of time in primary and secondary prevention of cardiovascular morbidity and mortality. Dr. Endo received Heinrich Wieland Prize for the discovery of HMG Co A reductase inhibitors from West Germany in 1987.

Dr. Endo was a professor at Tokyo University of Agriculture and Technology and also served as a president of Biopharma Research Laboratories. He was inducted into National Inventors Hall of Fame, Alexandria VA in 2012. Interestingly, Michael Stuart Brown and Joseph L Goldstein received Nobel Prize in 1985 for describing regulation of cholesterol metabolism. The millions of people whose lives will be extended through statin therapy owe it all to Akira Endo according these Nobel Laureates.

At the age of 87, Dr. Akira Endo is a living legend.

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