• Users Online: 226
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2018  |  Volume : 6  |  Issue : 1  |  Page : 9-17

Clinical Profile of an outbreak of Scrub Typhus in rural Bangaluru and significance of Hypoalbuminemia as a Predictor of complications


1 Senior Professor, MVJ Medical College, Hoskote, Bangalore, India
2 P G Student, MVJ Medical College, Hoskote, Bangalore, India

Correspondence Address:
Vasanth Kamath
Professor of Medicine, MVJ Medical College, Hoskote, Bangalore
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2666-1802.260114

Rights and Permissions

Aim: To identify scrub typhus infections and study their clinical manifestations, trend, outcome and the role of hypoalbuminemia as a predictor of complications for all confirmed cases admitted to a tertiary care hospital in Rural Bangalore. Materials and Methods: All cases of febrile illness diagnosed as scrub typhus based on a Weil-felix cut-off of >1:320 or a starting titre of 1:80 with a four-fold rising titre. Results: 63 cases of scrub typhus were seen over a period of 18 months (November 2015 to April 2017). Most of the cases occurred between November and January (83.3%). Common symptoms were high grade fever of 7-14 days duration, myalgia, headache, cough, vomiting and abdominal pain. Rash was seen in 31.7% cases and eschar in only 4.7% cases. Leucocytosis was seen in majority of cases79.1% and thrombocytopenia in 63.4%. Liver enzymes were elevated in 77.7%. Complications like Meningoen cephalitis in 4.7%, non-oliguric ARF in 12.6%,pleural effusion in 7.9%, acalculous cholecystitis in 3.1% and acute liver cell failure in 1.5%.Hypoalbuminemiais a powerful predictor of complications like acute renal failure, meningoencephalitis and acute cholecystitis in patients with Scrub typhus in our study. There was a dramatic response to doxycycline in nearly all the patients. Conclusion: Scrub Typhus is a re-emerging infection in India and is difficult to diagnose because of nonspecific signs, nonspecific symptoms and nonspecific presentation and the classical eschar is rarely seen. Complications of scrub typhus were significantly higher in patients with hypoalbuminemia as compared to normoalbuminemia. Doxycycline is very effective in scrub typhus, as most of our cases responded to it.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed558    
    Printed31    
    Emailed0    
    PDF Downloaded88    
    Comments [Add]    

Recommend this journal