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Year : 2020  |  Volume : 8  |  Issue : 1  |  Page : 22-23

Systemic lupus erythematosus and beta-thalassemia trait

Department of General Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India

Correspondence Address:
Dr. T A Shilpa
Bengaluru Medical College and Research Institute, Bengaluru, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/AJIM.AJIM_10_19

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Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that predominantly affects women of child-bearing age. The prevalence of beta-thalassemia in patients with SLE is lesser than the general population. When these two conditions coexist, however, SLE seems to have a more severe course. The following case report deals with a 34-year-old female who presented with severe dimorphic anemia and a positive direct Coombs test. On further evaluation, she was diagnosed with SLE based on a positive antineutrophilic antibody report and anti-Smith antibodies. A hemoglobin (Hb) electrophoresis was ordered for in view of the normal iron profile which revealed beta-thalassemia trait. An improvement in Hb and platelet counts was noted after initiating steroids. Although most hematological abnormalities are due to the disease (SLE) itself, it is important to remember that other causes such as thalassemia may coexist.

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